Plasma Concentrations of Loxtidine
نویسندگان
چکیده
The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related to the prolonged achlorhydria produced by this potent unsurmountable histamine H2 receptor antagonist.
منابع مشابه
The metabolism of loxtidine in rat and dog
Loxtidine hemisuccinate is a potent, long-acting H,-receptor antagonist under investigation as an anti-ulcer drug (Brittain & Jack, 1983). We have studied the metabolism of loxtidine hemisuccinate labelled with either 3H or I4C (Fig. I). Rats and dogs were given single oral doses of 1-50mg of I I4C lloxtidine base/kg body wt. In both species the compound was well absorbed with peak concentratio...
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